功能： Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. ; (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer . Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes . Involved in lipid droplet formation, which is important for HCV virion assembly .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection . Membrane, caveola . Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
组织表达： Widely expressed.
科研货号： PLA011834
PACSIN2 rabbit pAb
Catalog NoPLA011834
Product information
基因名称： PACSIN2
蛋白名称： Protein kinase C and casein kinase substrate in neurons protein 2
功能： Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. ; (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer . Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes . Involved in lipid droplet formation, which is important for HCV virion assembly .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection . Membrane, caveola . Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
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