功能： Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 . Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasmic vesicle membrane ; Peripheral membrane protein . Mitochondrion . Colocalizes with RAB11A on cytoplasmic vesicle membranes. .
组织表达： Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
科研货号： PLA011809
SH3BP5 rabbit pAb
Catalog NoPLA011809
Product information
基因名称： SH3BP5 SAB
蛋白名称： SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK)
功能： Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 . Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasmic vesicle membrane ; Peripheral membrane protein . Mitochondrion . Colocalizes with RAB11A on cytoplasmic vesicle membranes. .
组织表达： Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
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