功能： Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Lysosome . Colocalizes with intermediate filaments.
组织表达： Expressed in placenta, prostate and thymus.
科研货号： PLA011771
TRIM29 rabbit pAb
Catalog NoPLA011771
Product information
基因名称： TRIM29 ATDC
蛋白名称： Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein)
功能： Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Lysosome . Colocalizes with intermediate filaments.
在线咨询
湘公网安备