功能： Required for optimal lysosomal function . Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation . Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation . Plays a role as negative regulator of TGFB1 production in regulatory T cells . Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endomembrane system ; Multi-pass membrane protein . Late endosome membrane . Cell membrane . Cell projection . Lysosome membrane . Endosome membrane. Endosome, multivesicular body membrane . Endosome, multivesicular body lumen .
科研货号： PLA011747
LAPTM4B rabbit pAb
Catalog NoPLA011747
Product information
基因名称： LAPTM4B PSEC0001
蛋白名称： Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta)
功能： Required for optimal lysosomal function . Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation . Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation . Plays a role as negative regulator of TGFB1 production in regulatory T cells . Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endomembrane system ; Multi-pass membrane protein . Late endosome membrane . Cell membrane . Cell projection . Lysosome membrane . Endosome membrane. Endosome, multivesicular body membrane . Endosome, multivesicular body lumen .
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