功能： Involved in regulation of NF-kappa-B transcription factor complexes . Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation . Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer . Seems also to activate NF-kappa-B-mediated transcription . In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters . Promotes transcription of LCN2 and DEFB4 . Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Aggregated in dot-like structures (PubMed:16513645). Colocalizes with NCOR2 (PubMed:16513645). .
组织表达： Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
功能： Involved in regulation of NF-kappa-B transcription factor complexes . Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation . Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer . Seems also to activate NF-kappa-B-mediated transcription . In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters . Promotes transcription of LCN2 and DEFB4 . Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Aggregated in dot-like structures (PubMed:16513645). Colocalizes with NCOR2 (PubMed:16513645). .
组织表达： Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
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