功能： Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Chromosome, centromere, kinetochore . Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). .
组织表达： Ubiquitous; with lowest levels in spleen.
科研货号： PLA011593
CREST rabbit pAb
Catalog NoPLA011593
Product information
基因名称： SS18L1 CREST KIAA0693
蛋白名称： Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)
功能： Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Chromosome, centromere, kinetochore . Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). .
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