功能： Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex . Slows down the rate of inactivation of KCNC3 channels . Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion . Endoplasmic reticulum . Nucleus membrane . Cytoplasmic vesicle . Cytoplasm, cell cortex . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Sarcoplasmic reticulum . Cytoplasm, P-body .; [Isoform 1]: Cytoplasm . Nucleus . Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro). .; [Isoform 3]: Cytoplasm . Nucleus . Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). .; [Isoform 4]: Cytoplasm . Nucleus . Shuttles between nucleus and cytoplasm. .; [Isoform 5]: Cytoplasm . Predominantly cytoplasmic. .
组织表达： Ubiquitous. Up-regulated in oral cancers.
科研货号： PLA011587
HAX1 rabbit pAb
Catalog NoPLA011587
Product information
基因名称： HAX1 HS1BP1
蛋白名称： HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1)
功能： Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex . Slows down the rate of inactivation of KCNC3 channels . Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion . Endoplasmic reticulum . Nucleus membrane . Cytoplasmic vesicle . Cytoplasm, cell cortex . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Sarcoplasmic reticulum . Cytoplasm, P-body .; [Isoform 1]: Cytoplasm . Nucleus . Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro). .; [Isoform 3]: Cytoplasm . Nucleus . Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). .; [Isoform 4]: Cytoplasm . Nucleus . Shuttles between nucleus and cytoplasm. .; [Isoform 5]: Cytoplasm . Predominantly cytoplasmic. .
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