功能： May function as a chaperone that inhibits aggregation of misfolded proteins . Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling . May also regulate the UPR via the EIF2AK3 UPR sensor . Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum lumen . Cell membrane . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). .
组织表达： Expressed in platelets (at protein level).
科研货号： PLA011553
PDIA6 rabbit pAb
Catalog NoPLA011553
Product information
基因名称： PDIA6 ERP5 P5 TXNDC7
蛋白名称： Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
功能： May function as a chaperone that inhibits aggregation of misfolded proteins . Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling . May also regulate the UPR via the EIF2AK3 UPR sensor . Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum lumen . Cell membrane . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). .
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