功能： Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains . Involved in N-glycosylation of STT3B-dependent substrates . Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. ; May be involved in Mg(2+) transport in epithelial cells.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达： Ubiquitous. Expressed at very low levels in brain, lung and kidney.
科研货号： PLA011510
MAGT1 rabbit pAb
Catalog NoPLA011510
Product information
基因名称： MAGT1 IAG2 PSEC0084 UNQ628/PRO1244
蛋白名称： Magnesium transporter protein 1 (MagT1) (Implantation-associated protein) (IAP)
功能： Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains . Involved in N-glycosylation of STT3B-dependent substrates . Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. ; May be involved in Mg(2+) transport in epithelial cells.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达： Ubiquitous. Expressed at very low levels in brain, lung and kidney.
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