功能： ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair . Binds DNA . As part of the INO80 complex, remodels chromatin by shifting nucleosomes . Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator . Involved in UV-damage excision DNA repair . The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation . Involved in DNA replication . Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Chromosome . Localizes to the cytoplasm in quiescent cell (PubMed:20237820). Associates with spindle microtubules during mitosis (PubMed:20237820). Colocalizes with PCNA at replication forks during S-phase (PubMed:20237820). Recruited to DNA damage sites in a ACTR8-dependent manner (PubMed:20971067). .
组织表达： According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.
tag： hot
科研货号： PLA011482
INO80 rabbit pAb
Catalog NoPLA011482
Product information
基因名称： INO80 INO80A INOC1 KIAA1259
蛋白名称： DNA helicase INO80 (hINO80) (EC 3.6.4.12) (INO80 complex subunit A) (Putative DNA helicase INO80 complex homolog 1)
功能： ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair . Binds DNA . As part of the INO80 complex, remodels chromatin by shifting nucleosomes . Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator . Involved in UV-damage excision DNA repair . The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation . Involved in DNA replication . Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Chromosome . Localizes to the cytoplasm in quiescent cell (PubMed:20237820). Associates with spindle microtubules during mitosis (PubMed:20237820). Colocalizes with PCNA at replication forks during S-phase (PubMed:20237820). Recruited to DNA damage sites in a ACTR8-dependent manner (PubMed:20971067). .
组织表达： According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.
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