其他名称： Calcium homeostasis modulator protein 1; Protein FAM26C
实测条带： 40kD
功能： function:May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.,polymorphism:Leu-86 causes a dysregulation of Ca(2+) homeostasis and amyloid precursor protein (APP) metabolism, and may be a risk factor for the development of Alzheimer's disease.,similarity:Belongs to the FAM26 family.,subcellular location:Colocalizes with HSPA5 at the endoplasmic reticulum.,subunit:Homooligomer; homomultimerized to form dimeric and possibly tetrameric structures.,tissue specificity:Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein . Colocalizes with HSPA5 at the endoplasmic reticulum (PubMed:18585350). Localizes to the basolateral membrane of epithelial cells including taste cells (By similarity). .
组织表达： Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells.
其他名称： Calcium homeostasis modulator protein 1; Protein FAM26C
实测条带： 40kD
功能： function:May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.,polymorphism:Leu-86 causes a dysregulation of Ca(2+) homeostasis and amyloid precursor protein (APP) metabolism, and may be a risk factor for the development of Alzheimer's disease.,similarity:Belongs to the FAM26 family.,subcellular location:Colocalizes with HSPA5 at the endoplasmic reticulum.,subunit:Homooligomer; homomultimerized to form dimeric and possibly tetrameric structures.,tissue specificity:Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein . Colocalizes with HSPA5 at the endoplasmic reticulum (PubMed:18585350). Localizes to the basolateral membrane of epithelial cells including taste cells (By similarity). .
组织表达： Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells.
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