VEGF Rabbit Polyclonal Antibody

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商品货号： PLA011223

适应性： 人,大鼠,小鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： VEGFA
蛋白名称： VEGFA
Human_gene_id： 7422
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7422
Human_swiss_prot_no： P15692
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15692/entry
Mouse_swiss_prot_no： Q00731
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q00731
Rat_swiss_prot_no： P16612
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P16612
特异性： VEGF protein detects endogenous levels of VEGFA
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500-2000, IHC 1:50-300 IHC 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： VEGFA
实测条带： 21kD(monomer),42kD(dimer)
信号通路： Cytokine-cytokine receptor interaction;mTOR;VEGF;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;
功能： function:Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to VEGFR2/Kdr but doesn't activate downstream signaling pathways, doesn't activate angiogenesis and inhibits tumor growth.,induction:Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and oncogenic mutations.,online information:VEGF entry,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.,subunit:Homodimer; disulfide-linked. Also found as heterodimer with PlGF.,tissue specificity:The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the VEGF206 and VEGF-145 are uncommon.,
相关产品： YT5108,YT4870,YM3681,RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted . VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
组织表达： Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
科研货号： PLA011223

VEGF Rabbit Polyclonal Antibody

Catalog No PLA011223

Product information

基因名称： VEGFA
蛋白名称： VEGFA
Human_gene_id： 7422
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7422
Human_swiss_prot_no： P15692
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15692/entry
Mouse_swiss_prot_no： Q00731
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q00731
Rat_swiss_prot_no： P16612
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P16612
特异性： VEGF protein detects endogenous levels of VEGFA
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500-2000, IHC 1:50-300 IHC 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： VEGFA
实测条带： 21kD(monomer),42kD(dimer)
信号通路： Cytokine-cytokine receptor interaction;mTOR;VEGF;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;
功能： function:Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to VEGFR2/Kdr but doesn't activate downstream signaling pathways, doesn't activate angiogenesis and inhibits tumor growth.,induction:Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and oncogenic mutations.,online information:VEGF entry,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.,subunit:Homodimer; disulfide-linked. Also found as heterodimer with PlGF.,tissue specificity:The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the VEGF206 and VEGF-145 are uncommon.,
相关产品： YT5108,YT4870,YM3681,RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted . VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
组织表达： Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
科研货号： PLA011223

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