功能： domain:A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.,function:Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.,miscellaneous:In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.,PTM:The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Single-pass type I membrane protein.
组织表达： Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
功能： domain:A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.,function:Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.,miscellaneous:In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.,PTM:The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Single-pass type I membrane protein.
组织表达： Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
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