功能： disease:Crystallins do not turn over as the lens ages, providing ample opportunity for post-translational modifications or oxidations. These modifications may change crystallin solubility properties and favor senile cataract.,disease:Defects in CRYGC are a cause of autosomal dominant cataract [MIM:604219]. Cataract is an opacification of the eye lens that frequently results in visual impairment or blindness during infancy and early childhood.,disease:Defects in CRYGC are a cause of Coppock-like cataract (CCL) [MIM:604307]. The Coppock cataract refers to a congenital pulverulent disk-like opacity involving the embryonal and fetal nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited.,disease:Defects in CRYGC are the cause of variable zonular pulverulent cataract [MIM:123680].,domain:Has a two-domain beta-structure, folded into four very similar Greek key motifs.,function:Crystallins are the dominant structural components of the vertebrate eye lens.,mass spectrometry: PubMed:12876325,similarity:Belongs to the beta/gamma-crystallin family.,similarity:Contains 4 beta/gamma crystallin 'Greek key' domains.,subunit:Monomer.,
功能： disease:Crystallins do not turn over as the lens ages, providing ample opportunity for post-translational modifications or oxidations. These modifications may change crystallin solubility properties and favor senile cataract.,disease:Defects in CRYGC are a cause of autosomal dominant cataract [MIM:604219]. Cataract is an opacification of the eye lens that frequently results in visual impairment or blindness during infancy and early childhood.,disease:Defects in CRYGC are a cause of Coppock-like cataract (CCL) [MIM:604307]. The Coppock cataract refers to a congenital pulverulent disk-like opacity involving the embryonal and fetal nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited.,disease:Defects in CRYGC are the cause of variable zonular pulverulent cataract [MIM:123680].,domain:Has a two-domain beta-structure, folded into four very similar Greek key motifs.,function:Crystallins are the dominant structural components of the vertebrate eye lens.,mass spectrometry: PubMed:12876325,similarity:Belongs to the beta/gamma-crystallin family.,similarity:Contains 4 beta/gamma crystallin 'Greek key' domains.,subunit:Monomer.,
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