功能： alternative products:At least 5 different isozymes are produced by alternative splicing of 8 exons. The resultant proteins have different biochemical characteristics and substrate specificity,catalytic activity:Spermidine + O(2) + H(2)O = putrescine + 3-aminopropanal + H(2)O(2).,catalytic activity:Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2).,cofactor:Binds 1 FAD per subunit.,enzyme regulation:Inhibited at more than 90% by SL-11144, SL-11150 and SL-11158, at concentrations less than 1uM.,function:Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.,induction:By antitumor polyamine analogs.,pathway:Amine and polyamine degradation; spermine degradation.,similarity:Belongs to the flavin monoamine oxidase family.,tissue specificity:Widely expressed.,
功能： alternative products:At least 5 different isozymes are produced by alternative splicing of 8 exons. The resultant proteins have different biochemical characteristics and substrate specificity,catalytic activity:Spermidine + O(2) + H(2)O = putrescine + 3-aminopropanal + H(2)O(2).,catalytic activity:Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2).,cofactor:Binds 1 FAD per subunit.,enzyme regulation:Inhibited at more than 90% by SL-11144, SL-11150 and SL-11158, at concentrations less than 1uM.,function:Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.,induction:By antitumor polyamine analogs.,pathway:Amine and polyamine degradation; spermine degradation.,similarity:Belongs to the flavin monoamine oxidase family.,tissue specificity:Widely expressed.,
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