功能： domain:The CRIB domain mediates interaction with CDC42.,function:Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.,miscellaneous:CDC42SE2 is mapped in the genomic region associated with schizophrenia.,similarity:Belongs to the CDC42SE/SPEC family.,similarity:Contains 1 CRIB domain.,subcellular location:Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.,subunit:Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.,tissue specificity:Widely expressed. Expressed at higher level in T lymphocytes. Highly expressed in CCRF-CEM T lymphocytes, Jurkat T lymphocytes, and Raji B lymphocytes compared (at protein level).,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
组织表达： Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level).
功能： domain:The CRIB domain mediates interaction with CDC42.,function:Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.,miscellaneous:CDC42SE2 is mapped in the genomic region associated with schizophrenia.,similarity:Belongs to the CDC42SE/SPEC family.,similarity:Contains 1 CRIB domain.,subcellular location:Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.,subunit:Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.,tissue specificity:Widely expressed. Expressed at higher level in T lymphocytes. Highly expressed in CCRF-CEM T lymphocytes, Jurkat T lymphocytes, and Raji B lymphocytes compared (at protein level).,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
组织表达： Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level).
在线咨询
湘公网安备