功能： domain:The talin-like domain binds F-actin.,function:Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.,similarity:Belongs to the SLA2 family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 1 I/LWEQ domain.,subcellular location:Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.,subunit:Interacts with actin. Does not interact with huntingtin (By similarity). Interacts with CLTB and HIP1.,tissue specificity:Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
组织表达： Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
功能： domain:The talin-like domain binds F-actin.,function:Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.,similarity:Belongs to the SLA2 family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 1 I/LWEQ domain.,subcellular location:Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.,subunit:Interacts with actin. Does not interact with huntingtin (By similarity). Interacts with CLTB and HIP1.,tissue specificity:Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
组织表达： Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
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