功能： caution:According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.,domain:The guanine nucleotide exchange activity is autoinhibited by the PH domain.,function:Chloride/bicarbonate exchanger.,function:May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 STAS domain.,subcellular location:Highly colocalizes with actin regions.,subunit:Interacts with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1.,tissue specificity:Isoforms 1 and 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.,
功能： caution:According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.,domain:The guanine nucleotide exchange activity is autoinhibited by the PH domain.,function:Chloride/bicarbonate exchanger.,function:May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 STAS domain.,subcellular location:Highly colocalizes with actin regions.,subunit:Interacts with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1.,tissue specificity:Isoforms 1 and 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.,
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