其他名称： Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
实测条带： 60kD
功能： domain:Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains.,domain:The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are implicated in promotion of serum response element (SRE) activation. The SH3 domain interacts with focal adhesion kinase 1.,function:Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES.,PTM:Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC.,similarity:Belongs to the CAS family.,similarity:Contains 1 SH3 domain.,tissue specificity:The protein has been detected in lung and placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： cytoplasm,
组织表达： The protein has been detected in lung and placenta.
其他名称： Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
实测条带： 60kD
功能： domain:Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains.,domain:The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are implicated in promotion of serum response element (SRE) activation. The SH3 domain interacts with focal adhesion kinase 1.,function:Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES.,PTM:Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC.,similarity:Belongs to the CAS family.,similarity:Contains 1 SH3 domain.,tissue specificity:The protein has been detected in lung and placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： cytoplasm,
组织表达： The protein has been detected in lung and placenta.
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