其他名称： Zinc finger protein RFP (EC 6.3.2.-) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)
实测条带： 60kD
功能： disease:A chromosomal aberration involving TRIM27 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates RFP/RET and delta RFP/RET oncogenes.,domain:The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.,function:Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies.,subunit:Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1.,tissue specificity:Expressed in testis namely within the seminiferous tubules.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Early endosome . Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). .
组织表达： Expressed in testis namely within the seminiferous tubules.
其他名称： Zinc finger protein RFP (EC 6.3.2.-) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)
实测条带： 60kD
功能： disease:A chromosomal aberration involving TRIM27 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates RFP/RET and delta RFP/RET oncogenes.,domain:The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.,function:Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies.,subunit:Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1.,tissue specificity:Expressed in testis namely within the seminiferous tubules.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Early endosome . Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). .
组织表达： Expressed in testis namely within the seminiferous tubules.
在线咨询
湘公网安备