其他名称： Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4)
实测条带： 22kD
功能： domain:The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.,function:Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Probably acts by forming a redox cycle with GFER/ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.,PTM:Forms intrachain disulfide bridges, but exists in different redox states.,similarity:Contains 1 CHCH domain.,subunit:Forms homooligomer.,tissue specificity:Expressed in all tissues tested, suggesting an ubiquitous expression.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion intermembrane space .
组织表达： Expressed in all tissues tested, suggesting an ubiquitous expression.
其他名称： Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4)
实测条带： 22kD
功能： domain:The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.,function:Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Probably acts by forming a redox cycle with GFER/ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.,PTM:Forms intrachain disulfide bridges, but exists in different redox states.,similarity:Contains 1 CHCH domain.,subunit:Forms homooligomer.,tissue specificity:Expressed in all tissues tested, suggesting an ubiquitous expression.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion intermembrane space .
组织表达： Expressed in all tissues tested, suggesting an ubiquitous expression.
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