功能： function:Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. May be regulated upon PRKCA activation. May regulate ACCN3-ACCN2 heteromeric cation channel.,PTM:Phosphorylated.,similarity:Contains 1 AH domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Also present at excitatory synapses.,subunit:Monomer and homodimer. Interacts presynaptically with the monoamine transporters SLC6A2 and SLC6A3; with the channel proteins ACCN1 and ACCN2; with the GTP-binding proteins ARF1 and ARF3. Interacts with PRKCA; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; and with ERBB2. Interacts with BTG2; with the glutamate receptors GRIA2, GRIA3, the isoform A of GRM4, GRM7 and GRM8; and with NAPA and NAPB. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with UNC5A (By similarity). Interacts with CXADR. Interacts through its PDZ domain with the C-terminal tail of PRLHR.,tissue specificity:Ubiquitous.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, perinuclear region. Membrane ; Peripheral membrane protein . Membrane ; Lipid-anchor . Cell junction, synapse, postsynaptic density . Cell junction, synapse, synaptosome . Cytoplasm, cytoskeleton . Also membrane-associated, present at excitatory synapses. .
组织表达： Ubiquitous.
科研货号： PLA008774
PICK1 Polyclonal Antibody
Catalog NoPLA008774
Product information
基因名称： PICK1 PRKCABP
蛋白名称： PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein)
功能： function:Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. May be regulated upon PRKCA activation. May regulate ACCN3-ACCN2 heteromeric cation channel.,PTM:Phosphorylated.,similarity:Contains 1 AH domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Also present at excitatory synapses.,subunit:Monomer and homodimer. Interacts presynaptically with the monoamine transporters SLC6A2 and SLC6A3; with the channel proteins ACCN1 and ACCN2; with the GTP-binding proteins ARF1 and ARF3. Interacts with PRKCA; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; and with ERBB2. Interacts with BTG2; with the glutamate receptors GRIA2, GRIA3, the isoform A of GRM4, GRM7 and GRM8; and with NAPA and NAPB. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with UNC5A (By similarity). Interacts with CXADR. Interacts through its PDZ domain with the C-terminal tail of PRLHR.,tissue specificity:Ubiquitous.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, perinuclear region. Membrane ; Peripheral membrane protein . Membrane ; Lipid-anchor . Cell junction, synapse, postsynaptic density . Cell junction, synapse, synaptosome . Cytoplasm, cytoskeleton . Also membrane-associated, present at excitatory synapses. .
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