功能： disease:Genetic variations in TBX21 are associated with susceptibility to aspirin-induced asthma [MIM:208550]. Asthma is defined as a chronic inflammatory lung disease that is characterized by airway hyperreactivity, eosinophil inflammation, and mucus hypersecretion resulting in intermittent airway obstruction.,disease:Genetic variations in TBX21 are associated with susceptibility to asthma and nasal polyps [MIM:208550]. Nasal polyps is a chronic inflammatory disease of the paranasal sinus mucosa, leading to the protrusion of edematous polyps into the nasal cavities.,function:Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:T-cell specific.,
功能： disease:Genetic variations in TBX21 are associated with susceptibility to aspirin-induced asthma [MIM:208550]. Asthma is defined as a chronic inflammatory lung disease that is characterized by airway hyperreactivity, eosinophil inflammation, and mucus hypersecretion resulting in intermittent airway obstruction.,disease:Genetic variations in TBX21 are associated with susceptibility to asthma and nasal polyps [MIM:208550]. Nasal polyps is a chronic inflammatory disease of the paranasal sinus mucosa, leading to the protrusion of edematous polyps into the nasal cavities.,function:Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:T-cell specific.,
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