功能： developmental stage:Expressed during fetal development.,disease:Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.,disease:Defects in MYCN are the cause of Feingold syndrome [MIM:164280]; also known as oculodigitoesophagoduodenal syndrome (ODED). Feingold syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.,disease:Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence [MIM:602585].,function:May function as a transcription factor.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus.
组织表达： Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
科研货号： PLA008705
MYCN Polyclonal Antibody
Catalog NoPLA008705
Product information
基因名称： MYCN BHLHE37 NMYC
蛋白名称： N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
功能： developmental stage:Expressed during fetal development.,disease:Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.,disease:Defects in MYCN are the cause of Feingold syndrome [MIM:164280]; also known as oculodigitoesophagoduodenal syndrome (ODED). Feingold syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.,disease:Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence [MIM:602585].,function:May function as a transcription factor.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus.
组织表达： Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
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