信号通路： WNT;WNT-T CELLNotch;Melanogenesis;Pathways in cancer;Colorectal cancer;Basal cell carcinoma;
功能： disease:May be partly responsible for CATCH22 syndromes. This denomination includes developmental defects which associate cardiac defect, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia, and chromosome 22 deletions.,function:May play a role in the signal transduction pathway mediated by multiple Wnt genes.,PTM:Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction with INVS is required for ubiquitination.,similarity:Belongs to the DSH family.,similarity:Contains 1 DEP domain.,similarity:Contains 1 DIX domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE.,tissue specificity:Expressed in the thymus and, at high levels, in the heart.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Localizes at the cell membrane upon interaction with frizzled family members. .
信号通路： WNT;WNT-T CELLNotch;Melanogenesis;Pathways in cancer;Colorectal cancer;Basal cell carcinoma;
功能： disease:May be partly responsible for CATCH22 syndromes. This denomination includes developmental defects which associate cardiac defect, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia, and chromosome 22 deletions.,function:May play a role in the signal transduction pathway mediated by multiple Wnt genes.,PTM:Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction with INVS is required for ubiquitination.,similarity:Belongs to the DSH family.,similarity:Contains 1 DEP domain.,similarity:Contains 1 DIX domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE.,tissue specificity:Expressed in the thymus and, at high levels, in the heart.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Localizes at the cell membrane upon interaction with frizzled family members. .
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