功能： domain:The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.,function:Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.,similarity:Belongs to the PNMA family.,subunit:Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization.,tissue specificity:Ubiquitously expressed with higher levels in heart and brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytosol . Mitochondrion outer membrane . Extracellular vesicle membrane . Forms virion-like extracellular vesicles that are released from cells. .
组织表达： Widely expressed, with high levels in heart and brain.
科研货号： PLA008666
MOAP1 Polyclonal Antibody
Catalog NoPLA008666
Product information
基因名称： MOAP1 PNMA4
蛋白名称： Modulator of apoptosis 1 (MAP-1) (MAP1) (Paraneoplastic antigen Ma4)
功能： domain:The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.,function:Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.,similarity:Belongs to the PNMA family.,subunit:Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization.,tissue specificity:Ubiquitously expressed with higher levels in heart and brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytosol . Mitochondrion outer membrane . Extracellular vesicle membrane . Forms virion-like extracellular vesicles that are released from cells. .
组织表达： Widely expressed, with high levels in heart and brain.
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