功能： domain:Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus.,function:Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.,induction:Down-regulated in some cancer cell lines. Isoform Alpha induced by serum. Isoform Beta constitutively expressed.,similarity:Contains 1 LIM zinc-binding domain.,subcellular location:This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques.,tissue specificity:Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Cell junction, focal adhesion . Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber . Cell membrane . Expressed in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (PubMed:24694988). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity). .
组织表达： Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.
科研货号： PLA008646
LIMA1 Polyclonal Antibody
Catalog NoPLA008646
Product information
基因名称： LIMA1 EPLIN SREBP3 PP624
蛋白名称： LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
功能： domain:Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus.,function:Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.,induction:Down-regulated in some cancer cell lines. Isoform Alpha induced by serum. Isoform Beta constitutively expressed.,similarity:Contains 1 LIM zinc-binding domain.,subcellular location:This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques.,tissue specificity:Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Cell junction, focal adhesion . Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber . Cell membrane . Expressed in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (PubMed:24694988). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity). .
组织表达： Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.
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