功能： disease:Defects in HCRT are a cause of narcolepsy [MIM:161400]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.,function:Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.,online information:Qui dort dine - Issue 15 of October 2001,PTM:Specific enzymatic cleavages at paired basic residues yield the different active peptides.,similarity:Belongs to the orexin family.,subcellular location:Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.,tissue specificity:Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Rough endoplasmic reticulum . Cytoplasmic vesicle . Cell junction, synapse . Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. .
组织表达： Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
功能： disease:Defects in HCRT are a cause of narcolepsy [MIM:161400]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.,function:Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.,online information:Qui dort dine - Issue 15 of October 2001,PTM:Specific enzymatic cleavages at paired basic residues yield the different active peptides.,similarity:Belongs to the orexin family.,subcellular location:Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.,tissue specificity:Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Rough endoplasmic reticulum . Cytoplasmic vesicle . Cell junction, synapse . Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. .
组织表达： Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
在线咨询
湘公网安备