功能： disease:The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides.,function:Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.,miscellaneous:Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The Phe-203 in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.,polymorphism:There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA.,PTM:Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.,PTM:The soluble form is produced by a proteolytic cleavage.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Secreted after cleavage.,subunit:Monomer. Interacts with INPP5D/SHIP1.,tissue specificity:Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.,
功能： disease:The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides.,function:Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.,miscellaneous:Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The Phe-203 in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.,polymorphism:There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA.,PTM:Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.,PTM:The soluble form is produced by a proteolytic cleavage.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Secreted after cleavage.,subunit:Monomer. Interacts with INPP5D/SHIP1.,tissue specificity:Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.,
在线咨询
湘公网安备