功能： alternative products:Additional isoforms seem to exist,catalytic activity:Peptidylamidoglycolate = peptidyl amide + glyoxylate.,catalytic activity:Peptidylglycine + ascorbate + O(2) = peptidyl(2-hydroxyglycine) + dehydroascorbate + H(2)O.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Binds 2 copper ions per subunit; For the monoxygenase reaction.,cofactor:Zinc; for the lyase reaction.,enzyme regulation:Inhibited by EDTA, phenylglyoxal and diethyl pyrocarbonate.,function:Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.,similarity:Contains 5 NHL repeats.,similarity:In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.,similarity:In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.,subcellular location:Secreted from secretory granules.,subunit:Monomer. Interacts with RASSF9.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein . Secretory granules. .; [Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Secreted from secretory granules.; [Isoform 4]: Secreted. Secreted from secretory granules.
功能： alternative products:Additional isoforms seem to exist,catalytic activity:Peptidylamidoglycolate = peptidyl amide + glyoxylate.,catalytic activity:Peptidylglycine + ascorbate + O(2) = peptidyl(2-hydroxyglycine) + dehydroascorbate + H(2)O.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Binds 2 copper ions per subunit; For the monoxygenase reaction.,cofactor:Zinc; for the lyase reaction.,enzyme regulation:Inhibited by EDTA, phenylglyoxal and diethyl pyrocarbonate.,function:Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.,similarity:Contains 5 NHL repeats.,similarity:In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.,similarity:In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.,subcellular location:Secreted from secretory granules.,subunit:Monomer. Interacts with RASSF9.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein . Secretory granules. .; [Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Secreted from secretory granules.; [Isoform 4]: Secreted. Secreted from secretory granules.
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