功能： catalytic activity:Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.,cofactor:Binds 1 zinc ion per subunit.,developmental stage:Present in serum and placenta during pregnancy; levels increase throughout pregnancy.,enzyme regulation:Inhibited by complexation with the proform of PRG2.,function:Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.,induction:By 8-bromoadenosine-3',5'-phosphate.,PTM:There appear to be no free sulfhydryl groups.,similarity:Belongs to the peptidase M43B family.,similarity:Contains 5 Sushi (CCP/SCR) domains.,subunit:Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.,tissue specificity:Expressed in placenta with lower expression in brain, kidney and testis.,tissue specificity:High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted .
组织表达： High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
科研货号： PLA008125
PAPP1 Polyclonal Antibody
Catalog NoPLA008125
Product information
基因名称： PAPPA
蛋白名称： Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)
功能： catalytic activity:Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.,cofactor:Binds 1 zinc ion per subunit.,developmental stage:Present in serum and placenta during pregnancy; levels increase throughout pregnancy.,enzyme regulation:Inhibited by complexation with the proform of PRG2.,function:Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.,induction:By 8-bromoadenosine-3',5'-phosphate.,PTM:There appear to be no free sulfhydryl groups.,similarity:Belongs to the peptidase M43B family.,similarity:Contains 5 Sushi (CCP/SCR) domains.,subunit:Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.,tissue specificity:Expressed in placenta with lower expression in brain, kidney and testis.,tissue specificity:High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted .
组织表达： High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
在线咨询
湘公网安备