功能： developmental stage:Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.,function:Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.,miscellaneous:No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.,PTM:Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.,PTM:Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the nuclear hormone receptor family. NR3 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2.,tissue specificity:Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
科研货号： PLA008037
ERR3 Polyclonal Antibody
Catalog NoPLA008037
Product information
基因名称： ESRRG ERR3 ERRG2 KIAA0832 NR3B3
蛋白名称： Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
功能： developmental stage:Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.,function:Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.,miscellaneous:No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.,PTM:Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.,PTM:Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the nuclear hormone receptor family. NR3 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2.,tissue specificity:Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
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