功能： disease:Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS) [MIM:607313]. Patients show a medulla where motor and sensory projections appear uncrossed.,function:Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing.,similarity:Belongs to the immunoglobulin superfamily. ROBO family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Probably interacts with SLIT2.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Single-pass type I membrane protein .
组织表达： Brain,
科研货号： PLA008009
ROBO3 Polyclonal Antibody
Catalog NoPLA008009
Product information
基因名称： ROBO3
蛋白名称： Roundabout homolog 3 (Roundabout-like protein 3)
功能： disease:Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS) [MIM:607313]. Patients show a medulla where motor and sensory projections appear uncrossed.,function:Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing.,similarity:Belongs to the immunoglobulin superfamily. ROBO family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Probably interacts with SLIT2.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Single-pass type I membrane protein .
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