功能： disease:Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance.,function:May affect the rate of fibrils formation.,PTM:The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily.,similarity:Contains 12 LRR (leucine-rich) repeats.,subunit:Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.,
功能： disease:Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance.,function:May affect the rate of fibrils formation.,PTM:The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily.,similarity:Contains 12 LRR (leucine-rich) repeats.,subunit:Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.,
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