功能： cofactor:Contains 1 lysine tyrosylquinone.,cofactor:Copper.,PTM:The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.,similarity:Belongs to the lysyl oxidase family.,similarity:Contains 4 SRCR domains.,tissue specificity:Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted, extracellular space, extracellular matrix, basement membrane . Nucleus . Chromosome . Endoplasmic reticulum . Associated with chromatin (PubMed:27735137). It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted (PubMed:23319596). However, a number of reports confirm its intracellular location and its key role in transcription regulation (PubMed:22204712, PubMed:22483618). .
组织表达： Expressed in many tissues (PubMed:10212285). Highest expression in reproductive tissues, placenta, uterus and prostate (PubMed:10212285). In esophageal epithelium, expressed in the basal, prickle and granular cell layers (PubMed:22204712). Up-regulated in a number of cancers cells and tissues.
科研货号： PLA007953
LOXL2 Polyclonal Antibody
Catalog NoPLA007953
Product information
基因名称： LOXL2
蛋白名称： Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14)
功能： cofactor:Contains 1 lysine tyrosylquinone.,cofactor:Copper.,PTM:The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.,similarity:Belongs to the lysyl oxidase family.,similarity:Contains 4 SRCR domains.,tissue specificity:Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted, extracellular space, extracellular matrix, basement membrane . Nucleus . Chromosome . Endoplasmic reticulum . Associated with chromatin (PubMed:27735137). It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted (PubMed:23319596). However, a number of reports confirm its intracellular location and its key role in transcription regulation (PubMed:22204712, PubMed:22483618). .
组织表达： Expressed in many tissues (PubMed:10212285). Highest expression in reproductive tissues, placenta, uterus and prostate (PubMed:10212285). In esophageal epithelium, expressed in the basal, prickle and granular cell layers (PubMed:22204712). Up-regulated in a number of cancers cells and tissues.
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