功能： catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 KIND domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,similarity:Contains 3 PDZ (DHR) domains.,similarity:Contains 4 PDZ (DHR) domains.,similarity:Contains 5 PDZ (DHR) domains.,subunit:Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29.,tissue specificity:Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytoskeleton . Nucleus . Cell projection, lamellipodium . Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191). .
组织表达： Expressed in keratinocytes (at protein level) (PubMed:29043977). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.
功能： catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 KIND domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,similarity:Contains 3 PDZ (DHR) domains.,similarity:Contains 4 PDZ (DHR) domains.,similarity:Contains 5 PDZ (DHR) domains.,subunit:Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29.,tissue specificity:Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytoskeleton . Nucleus . Cell projection, lamellipodium . Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191). .
组织表达： Expressed in keratinocytes (at protein level) (PubMed:29043977). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.
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