功能： function:Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.,miscellaneous:The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.,similarity:Belongs to the MHC class I family.,subunit:Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.,tissue specificity:Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Lipid-anchor, GPI-anchor . Endoplasmic reticulum . Secreted . In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi. .
组织表达： Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
科研货号： PLA007899
N2DL2 Polyclonal Antibody
Catalog NoPLA007899
Product information
基因名称： ULBP2 N2DL2 RAET1H UNQ463/PRO791
蛋白名称： NKG2D ligand 2 (N2DL-2) (NKG2DL2) (ALCAN-alpha) (Retinoic acid early transcript 1H) (UL16-binding protein 2)
功能： function:Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.,miscellaneous:The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.,similarity:Belongs to the MHC class I family.,subunit:Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.,tissue specificity:Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Lipid-anchor, GPI-anchor . Endoplasmic reticulum . Secreted . In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi. .
组织表达： Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
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