功能： disease:Defects in MXI1 are found in some patients with prostate cancer (CaP) [MIM:176807].,function:Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17.,tissue specificity:High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus.
组织表达： High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
科研货号： PLA007897
MXI1 Polyclonal Antibody
Catalog NoPLA007897
Product information
基因名称： MXI1 BHLHC11
蛋白名称： Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11)
功能： disease:Defects in MXI1 are found in some patients with prostate cancer (CaP) [MIM:176807].,function:Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17.,tissue specificity:High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus.
组织表达： High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
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