信号通路： Cysteine and methionine metabolism;Taurine and hypotaurine metabolism;
功能： catalytic activity:L-cysteine + O(2) = 3-sulfinoalanine.,cofactor:Binds 1 iron ion per subunit. Zinc to a much lesser extent.,cofactor:IRON; NAD(P)H.,function:Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.,induction:In hepatoblastoma HepG2 cells, down-regulated by phorbol 12-myristate 13-acetate.,pathway:Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.,PTM:The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.,similarity:Belongs to the cysteine dioxygenase family.,subunit:Monomer.,tissue specificity:Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma HepG2 cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： cytosol,
组织表达： Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.
科研货号： PLA007833
CDO1 Polyclonal Antibody
Catalog NoPLA007833
Product information
基因名称： CDO1
蛋白名称： Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)
信号通路： Cysteine and methionine metabolism;Taurine and hypotaurine metabolism;
功能： catalytic activity:L-cysteine + O(2) = 3-sulfinoalanine.,cofactor:Binds 1 iron ion per subunit. Zinc to a much lesser extent.,cofactor:IRON; NAD(P)H.,function:Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.,induction:In hepatoblastoma HepG2 cells, down-regulated by phorbol 12-myristate 13-acetate.,pathway:Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.,PTM:The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.,similarity:Belongs to the cysteine dioxygenase family.,subunit:Monomer.,tissue specificity:Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma HepG2 cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： cytosol,
组织表达： Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.
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