功能： domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.,function:Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.,induction:Down-regulated in activated leukocytes recruited to a site of inflammation.,PTM:Highly N-glycosylated. Glycosylation varies between cell types.,similarity:Contains 1 C-type lectin domain.,subcellular location:Ligand binding leads to internalization.,subunit:Homodimer. Interacts with PTPN6 and PTPN11.,subunit:Interacts with PTPN6 and PTPN11.,tissue specificity:Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis.,tissue specificity:Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type II membrane protein . Ligand binding leads to internalization.
组织表达： Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
科研货号： PLA007804
CL12A Polyclonal Antibody
Catalog NoPLA007804
Product information
基因名称： CLEC12A CLL1 DCAL2 MICL
蛋白名称： C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Myeloid inhibitory C-type lectin-like receptor) (MICL)
功能： domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.,function:Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.,induction:Down-regulated in activated leukocytes recruited to a site of inflammation.,PTM:Highly N-glycosylated. Glycosylation varies between cell types.,similarity:Contains 1 C-type lectin domain.,subcellular location:Ligand binding leads to internalization.,subunit:Homodimer. Interacts with PTPN6 and PTPN11.,subunit:Interacts with PTPN6 and PTPN11.,tissue specificity:Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis.,tissue specificity:Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type II membrane protein . Ligand binding leads to internalization.
组织表达： Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
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