功能： function:Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.,online information:SUMO protein entry,polymorphism:Variant Val-55 could be associated with insulin-dependent diabetes mellitus 5 (IDDM5) [MIM:600320].,PTM:In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.,similarity:Belongs to the ubiquitin family. SUMO subfamily.,similarity:Contains 1 ubiquitin-like domain.,subunit:Interacts with SAE2. Covalently attached to a number of proteins.,tissue specificity:Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： nucleus,
组织表达： Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
科研货号： PLA007738
SUMO4 Polyclonal Antibody
Catalog NoPLA007738
Product information
基因名称： SUMO4 SMT3H4
蛋白名称： Small ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4)
功能： function:Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.,online information:SUMO protein entry,polymorphism:Variant Val-55 could be associated with insulin-dependent diabetes mellitus 5 (IDDM5) [MIM:600320].,PTM:In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.,similarity:Belongs to the ubiquitin family. SUMO subfamily.,similarity:Contains 1 ubiquitin-like domain.,subunit:Interacts with SAE2. Covalently attached to a number of proteins.,tissue specificity:Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： nucleus,
组织表达： Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
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