功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers.,function:Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.,PTM:Phosphorylated on serine residue(s).,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 CRAL-TRIO domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 DH (DBL-homology) domains.,similarity:Contains 2 PH domains.,similarity:Contains 2 SH3 domains.,similarity:Contains 4 spectrin repeats.,subunit:Interacts to form a complex with leukocyte antigen related protein.,tissue specificity:Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell projection .
组织表达： Widely expressed, with highest levels in heart, skeletal muscle, and brain.
科研货号： PLA007727
TRIO Polyclonal Antibody
Catalog NoPLA007727
Product information
基因名称： TRIO
蛋白名称： Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers.,function:Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.,PTM:Phosphorylated on serine residue(s).,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 CRAL-TRIO domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 DH (DBL-homology) domains.,similarity:Contains 2 PH domains.,similarity:Contains 2 SH3 domains.,similarity:Contains 4 spectrin repeats.,subunit:Interacts to form a complex with leukocyte antigen related protein.,tissue specificity:Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell projection .
组织表达： Widely expressed, with highest levels in heart, skeletal muscle, and brain.
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