功能： function:A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.,PTM:Exists predominantly in a mono- or diubiquitinated form.,similarity:Contains 1 DED (death effector) domain.,subcellular location:Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells.,subunit:Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.,tissue specificity:Widely expressed with highest levels in testis.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Nucleus, nucleolus . Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. .
组织表达： Widely expressed with highest levels in testis.
科研货号： PLA007580
DEDD Polyclonal Antibody
Catalog NoPLA007580
Product information
基因名称： DEDD DEDPRO1 DEFT KE05
蛋白名称： Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1)
功能： function:A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.,PTM:Exists predominantly in a mono- or diubiquitinated form.,similarity:Contains 1 DED (death effector) domain.,subcellular location:Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells.,subunit:Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.,tissue specificity:Widely expressed with highest levels in testis.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Nucleus, nucleolus . Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. .
组织表达： Widely expressed with highest levels in testis.
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