功能： function:Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.,induction:Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid in lung cancer cells (at protein level).,miscellaneous:Subject to X inactivation.,miscellaneous:Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.,PTM:Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.,similarity:Belongs to the nucleosome assembly protein (NAP) family.,subcellular location:Enriched in transcriptionally active regions of chromatin in neurons.,subunit:Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2.,tissue specificity:Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Enriched in transcriptionally active regions of chromatin in neurons. .
组织表达： Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
科研货号： PLA007548
TSYL2 Polyclonal Antibody
Catalog NoPLA007548
Product information
基因名称： TSPYL2 CDA1 DENTT TSPX HRIHFB2216
蛋白名称： Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79)
功能： function:Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.,induction:Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid in lung cancer cells (at protein level).,miscellaneous:Subject to X inactivation.,miscellaneous:Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.,PTM:Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.,similarity:Belongs to the nucleosome assembly protein (NAP) family.,subcellular location:Enriched in transcriptionally active regions of chromatin in neurons.,subunit:Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2.,tissue specificity:Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Enriched in transcriptionally active regions of chromatin in neurons. .
组织表达： Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
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