功能: domain:The coiled-coil domain mediates oligomerization.,function:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.,induction:Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).,similarity:Belongs to the HEXIM family.,subunit:Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.,tissue specificity:Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Nucleus .
组织表达: Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
科研货号: PLA007527
HEXI2 Polyclonal Antibody
Catalog NoPLA007527
Product information
基因名称: HEXIM2 L3
蛋白名称: Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2)
功能: domain:The coiled-coil domain mediates oligomerization.,function:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.,induction:Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).,similarity:Belongs to the HEXIM family.,subunit:Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.,tissue specificity:Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Nucleus .
组织表达: Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.