功能： function:Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). May act as a tumor suppressor protein in osteogenic sarcoma (OGS).,induction:By GDNF.,miscellaneous:Down-regulated in OGS biopsy.,similarity:Belongs to the 5'-3' exonuclease family.,subcellular location:Discrete foci at the inner surface of the cell membrane.,subunit:Associates with alpha and beta tubulins (By similarity). Found in a mRNP complex with RENT1, RENT2, RENT3B and XRN1.,tissue specificity:Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Discrete foci at the inner surface of the cell membrane.
组织表达： Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.
科研货号： PLA007509
XRN1 Polyclonal Antibody
Catalog NoPLA007509
Product information
基因名称： XRN1 SEP1
蛋白名称： 5'-3' exoribonuclease 1 (EC 3.1.11.-) (Strand-exchange protein 1 homolog)
功能： function:Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). May act as a tumor suppressor protein in osteogenic sarcoma (OGS).,induction:By GDNF.,miscellaneous:Down-regulated in OGS biopsy.,similarity:Belongs to the 5'-3' exonuclease family.,subcellular location:Discrete foci at the inner surface of the cell membrane.,subunit:Associates with alpha and beta tubulins (By similarity). Found in a mRNP complex with RENT1, RENT2, RENT3B and XRN1.,tissue specificity:Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Discrete foci at the inner surface of the cell membrane.
组织表达： Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.
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