功能： caution:This protein has lost active site residues and zinc-binding sites and so is unlikely to be catalytically active.,function:May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor.,PTM:Phosphorylated by MAPK1 in vitro.,similarity:Belongs to the peptidase M14 family.,similarity:Contains 1 F5/8 type C domain.,subunit:Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By similarity). Binds to DNA in vitro.,tissue specificity:Expressed in osteoblast and visceral fat.,
功能： caution:This protein has lost active site residues and zinc-binding sites and so is unlikely to be catalytically active.,function:May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor.,PTM:Phosphorylated by MAPK1 in vitro.,similarity:Belongs to the peptidase M14 family.,similarity:Contains 1 F5/8 type C domain.,subunit:Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By similarity). Binds to DNA in vitro.,tissue specificity:Expressed in osteoblast and visceral fat.,
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