功能： cofactor:Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions.,function:Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.,pharmaceutical:Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1.,PTM:Phosphorylated by ABL2/ARG in response to oxidative stress.,subcellular location:In the nucleus, accumulates in dot-like structures.,subunit:Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2.,tissue specificity:Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . In the nucleus, accumulates in dot-like structures.
组织表达： Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
科研货号： PLA007465
SIVA Polyclonal Antibody
Catalog NoPLA007465
Product information
基因名称： SIVA1 SIVA
蛋白名称： Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP)
功能： cofactor:Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions.,function:Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.,pharmaceutical:Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1.,PTM:Phosphorylated by ABL2/ARG in response to oxidative stress.,subcellular location:In the nucleus, accumulates in dot-like structures.,subunit:Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2.,tissue specificity:Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . In the nucleus, accumulates in dot-like structures.
组织表达： Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
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