功能： domain:The transmembrane domain also contains the signal for ER targeting.,domain:The UBX domain is required for interaction with VCP.,function:Involved in endoplasmic reticulum-associated protein degradation (ERAD).,induction:By ER stress-inducing reagents, such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBX domain.,subcellular location:Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER.,subunit:Directly interacts with VCP.,tissue specificity:Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus envelope . Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER. .
组织表达： Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
科研货号： PLA007351
UBXN4 Polyclonal Antibody
Catalog NoPLA007351
Product information
基因名称： UBXN4 KIAA0242 UBXD2 UBXDC1
蛋白名称： UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)
功能： domain:The transmembrane domain also contains the signal for ER targeting.,domain:The UBX domain is required for interaction with VCP.,function:Involved in endoplasmic reticulum-associated protein degradation (ERAD).,induction:By ER stress-inducing reagents, such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBX domain.,subcellular location:Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER.,subunit:Directly interacts with VCP.,tissue specificity:Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus envelope . Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER. .
组织表达： Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
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