功能： catalytic activity:Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).,disease:Defects in BAP1 are found in non-small cell lung cancer (NSCLC) cell lines.,disease:Tumor-associated antigen found in several childhood medulloblastoma.,function:Deubiquitinating enzyme which may be involved in BRCA1 signal transduction pathway.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase C12 family.,subunit:Interacts with the RING finger domain of BRCA1.,tissue specificity:Highly expressed in testis, placenta and ovary. Expressed in breast.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). .
组织表达： Highly expressed in testis, placenta and ovary. Expressed in breast.
科研货号： PLA007328
BAP1 Polyclonal Antibody
Catalog NoPLA007328
Product information
基因名称： BAP1 KIAA0272 hucep-6
蛋白名称： Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6)
功能： catalytic activity:Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).,disease:Defects in BAP1 are found in non-small cell lung cancer (NSCLC) cell lines.,disease:Tumor-associated antigen found in several childhood medulloblastoma.,function:Deubiquitinating enzyme which may be involved in BRCA1 signal transduction pathway.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase C12 family.,subunit:Interacts with the RING finger domain of BRCA1.,tissue specificity:Highly expressed in testis, placenta and ovary. Expressed in breast.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). .
组织表达： Highly expressed in testis, placenta and ovary. Expressed in breast.
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